Rosetta 3.4 was released on March 29th, 2012. The release is comprised of many new applications and features like Noncanonical amino acid utilities, Point mutant scan, New RNA applications and many more!

To learn more about the new functionality of Rosetta go to http://www.rosettacommons.org/manual_guide.


In addition, you can find here a comprehensive documentation for Rosetta-3.4.

To download Rosetta-3.4 go to http://www.rosettacommons.org/software.

RosettaCON2012 - The Annual Conference of Rosetta

This years Rosetta developers conference will be held in Leavenworth, WA, from July 29th to August 1st. RosettaCon 2012 is by invitation only.

RosettaCON2011 Tutorials Collection

We are excited to announce the release of the RosettaCON2011 Tutorials Collection. Rosetta's traditional documentation is often focused on documenting from the point of view of a developer or an executable: it answers, "what is every single thing a chunk of code can do, and how do you do it"? These tutorials are instead designed to guide users through sample procedures in computational modeling from the point of view of solving the problem. All use Rosetta, but they are designed to encompass a problem from start to finish and may include steps outside of Rosetta. Many use executables in ways not originally intended and wander outside their documented scope. Many use several different executables in the course of solving a problem.
For feedback and suggestions for further tutorials, please see this forum thread: http://www.rosettacommons.org/content/rosetta3-tutorials

To download RosettaCON2011 Tutorials Collection go to http://www.rosettacommons.org/software.

RosettaMultigraft is available!

RosettaMultigraft enables grafting of discontinuous structural motifs to scaffold proteins. The code includes a matching stage to identify appropriate scaffolds from a structural database and a design stage to perform the grafting and optimization. Backbone-grafting employing flexible backbone design is included. The method and its utility to guide design of directed mutagenesis libraries was recently presented in "Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold" Azoitei, et al. Science 334: 373-376 (2011). Currently, Multigraft is only available in an earlier C++ release of Rosetta, but efforts are underway to port Multigraft to the newest versions.

To download RosettaMultigraft go to http://www.rosettacommons.org/software.

Updated version of Rosetta 3.3 is available!

A week ago Rosetta 3.3 was put on hold on the RosettaCommons website, due to problems with the rosetta_database directory.

If you downloaded Rosetta3.3 before 9/6/11, please download the file rosetta_database.tgz again and replace the original corresponding file.
The Rosetta Community

PLoS One Special collection: RosettaCon 2010

The "PLoS One Special collection: RosettaCon 2010" has been released! The special collection can be found here http://www.ploscollections.org/static/poneCollections.action. One of the major goals of the release of the articles in this collection is to focus on not only the new science being done with Rosetta but also on how the Rosetta community uses Rosetta as part of a complete workflow. Running Rosetta is more than just typing a command line and we have aimed to capture the entire workflow required to reproduce the science described in the each article of the collection. These workflows, which include example inputs, outputs, and processing scripts are called "protocol captures" and can be used to reproduce the results described in the article or as the basis for extending or adapting the protocol to your system.



The protocol captures are included as part of the Rosetta 3.3 release but are also available individually here: Download Protocol Captures .
Neither the Rosetta software or a Rosetta license is required to download and examine the protocol captures. If however you wish to perform the steps in the protocol capture you will need to obtain a copy of Rosetta. Instructions for doing so can be found at http://www.rosettacommons.org/software.



Note: Not all protocol captures are compatible with Rosetta 3.3. Individual protocol captures describe the specific version of Rosetta (and any other software) required to run them.

Rosetta 3.3 is Now Available

Rosetta 3.3 was released on July 26th, 2011. The release is comprised of many new applications and features like Rosetta Antibody, RNA suite, Anchored Design suite and many more!

To learn more about the new functionality of Rosetta go to http://www.rosettacommons.org/manual_guide.


In addition, you can find here a comprehensive documentation for Rosetta-3.3.

To download Rosetta-3.3 go to http://www.rosettacommons.org/software.

New Patch For Rosetta

Rosetta 3.2.1 was released on March 8th, 2011. The release includes all the applications from Rosetta 3.2 and in addition a new application RosettaDNA, which was developed for protein-DNA interface modeling and design.

To download Rosetta-3.2.1 go to http://www.rosettacommons.org/software.

Our Goal

The Rosetta Commons aims to develop high resolution protein prediction and design software. The Commons provides an environment for continuous sharing and collaborative development of the Rosetta software suite. The Commons facilitates interaction among participating institutions and researchers and makes the Rosetta software broadly available to the scientific community.

Software

The Rosetta software suite focuses on the prediction and design of protein structures, protein folding mechanisms, and protein-protein interactions. Rosetta has been consistently successful in CASP and CAPRI competitions. Rosetta also addresses aspects of protein design, docking and structure. The software is the foundation for the Human Proteome Folding Project on the World Community Grid and the Roseta@home distributed computing project.

The Rosetta software suite is currently licensed for free to users at academic and nonprofit institutions. Over 2000 academic users in more than 32 countries use Rosetta. Commercial entities can use Rosetta by paying a license fee. Revenue from licensing is reinvested in supporting continued software development.

Our Research

	Structures of designed enzymes. Jiang L, et al (2008). De novo computational design of retro-aldol enzymes.Science 319, 1387-91.
	1.6 Å C{alpha}-RMSD blind structure prediction for CASP6 target T0281, hypothetical protein from Thermus thermophilus Hb8.(Bradley P, Misura KM, Baker D, (2005) Science. 309:1868-71.)
	Ribbon diagrams of Top7 with residues 46 to 76 highlighted in red -- A novel protein structure created with RosettaDesign.(Kuhlman B, Dantas G, Ireton GC, Varani G, Stoddard BL, Baker D, Science 302, 1364-8.)