Rosetta is available to academic and commercial researchers through a license.
Rosetta++ is free for academic and non-profit users.
Rosetta++ can be licensed for commercial use with the commercial license.
If you would like an evaluation license for Rosetta++, please contact us.
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| Examples of Accurate Predictions with Native-like Insert Domain Orientation and Side-Chain Packing. Signal-processing protein (1owq; Cgreek small letter alpha rmsd = 0.70 Å).M. Berrondo, M. Ostermeier & J. J. Gray, Structure 16(4), 513-527 (2008).This feature is in release 2.3 |
ROSETTA++ is a software suite for predicting and designing protein structures, protein folding mechanisms, and protein-protein interactions. The ROSETTA++ codes have been successful in the Critical Assessment of Techniques for Protein Structure Prediction (CASP) competitions.
| RosettaAbinitio | Performs de novo protein structure prediction. |
| RosettaDesign | Dentifies low free energy sequences for target protein backbones. |
| RosettaDesign pymol plugin | A user-friendly interface for submitting Protein Design simulations using RosettaDesign. |
| RosettaDock | Predicts the structure of a protein-protein complex from the individual structures of the monomer components. |
| RosettaFragments | Generates fragment libraries for use by Rosetta ab initio in building protein structures. |
| RosettaNMR | Incorporates NMR data into the basic Rosetta protocol to accelerate the process of NMR structure prediction |
| RosettaDNA | For the design of proteins that interact with specified DNA sequences. |
| RosettaRNA | Fragment assembly of RNA. |
| RosettaLigand | For small molecule - protein docking |
Rosetta development began in the laboratory of Dr. David Baker, who is a Howard Hughes Medical Institute investigator as well as a professor in the Department of Biochemistry. Rosetta development is guided by the members of the Rosetta Commons, which is a collaborative research and software development environment of multiple universities and research institutes. Funding for the development of Rosetta has been provided by the Packard Foundation, the National Science Foundation, and the National Institutes of Health.