Rosetta is available to academic and commercial researchers through a license.
Rosetta Software is free for academic and non-profit users.
Rosetta Software can be licensed for commercial use with the commercial license.
If you would like a license for Rosetta Software, please contact us.
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A license must first be obtained through this site to login and download software.
PyRosetta is available through http://www.pyrosetta.org/.
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| Examples of Accurate Predictions with Native-like Insert Domain Orientation and Side-Chain Packing. Signal-processing protein (1owq; Cgreek small letter alpha rmsd = 0.70 Å).M. Berrondo, M. Ostermeier & J. J. Gray, Structure 16(4), 513-527 (2008).This feature is in release 2.3 |
| RosettaAbinitio | Performs de novo protein structure prediction. |
| RosettaDesign | Identifies low free energy sequences for target protein backbones. |
| RosettaDesign pymol plugin | A user-friendly interface for submitting Protein Design simulations using RosettaDesign. |
| RosettaDock | Predicts the structure of a protein-protein complex from the individual structures of the monomer components. |
| RosettaAntibody | Predicts antibody Fv region structures and performs antibody-antigen docking. |
| RosettaFragments | Generates fragment libraries for use by Rosetta ab initio in building protein structures. |
| RosettaNMR | Incorporates NMR data into the basic Rosetta protocol to accelerate the process of NMR structure prediction |
| RosettaDNA | For the design of proteins that interact with specified DNA sequences. |
| RosettaRNA | Fragment assembly of RNA. |
| RosettaLigand | For small molecule - protein docking |
| RosettaSymmetry | For enforcing symmetry in Rosetta |
| RosettaEnzdes | For enzyme design |
| RosettaMembrane | For membrane protein ab initio modeling |
| RosettaDDG | For estimating the impact of sequence changes on protein stability |
| RosettaScripts | An xml-based scripting language for control of modeling trajectories. Supports all major Rosetta functionalities |
| RosettaSnugDock | Enables docking an antibody Fv region to an antigen and allows backbone flexibility in the paratope. |
| RosettaMultigraft | Performs matching, backbone, and side chain grafting of functional motifs onto scaffold proteins. |
The following applications are located only in the previous releases of Rosetta: RosettaDDG, RosettaAntibody and RosettaSnugDock
PyRosetta is an interactive Python-based interface to the powerful Rosetta molecular modeling suite. It enables users to design their own custom molecular modeling algorithms using Rosetta sampling methods and energy functions. PyRosetta is available through http://www.pyrosetta.org/.
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Rosetta development began in the laboratory of Dr. David Baker, who is a Howard Hughes Medical Institute investigator as well as a professor in the Department of Biochemistry. Rosetta development is guided by the members of the Rosetta Commons, which is a collaborative research and software development environment of multiple universities and research institutes. Funding for the development of Rosetta has been provided by the Packard Foundation, the National Science Foundation, and the National Institutes of Health.