Software

Rosetta Software Suite

ROSETTA is a software suite for predicting and designing protein structures, protein folding mechanisms, and protein-protein interactions. ROSETTA has been consistently successful in CASP and CAPRI competitions.

Software Functionality Summary

RosettaAbinitioPerforms de novo protein structure prediction.
RosettaDesignIdentifies low free energy sequences for target protein backbones.
RosettaDesign pymol pluginA user-friendly interface for submitting Protein Design simulations using RosettaDesign.
RosettaDockPredicts the structure of a protein-protein complex from the individual structures of the monomer components.
RosettaAntibodyPredicts antibody Fv region structures and performs antibody-antigen docking.
RosettaFragmentsGenerates fragment libraries for use by Rosetta ab initio in building protein structures.
RosettaNMRIncorporates NMR data into the basic Rosetta protocol to accelerate the process of NMR structure prediction
RosettaDNAFor the design of proteins that interact with specified DNA sequences.
RosettaRNAFragment assembly of RNA.
RosettaLigandFor small molecule - protein docking
RosettaSymmetryFor enforcing symmetry in Rosetta
RosettaEnzdesFor enzyme design
RosettaMembraneFor membrane protein ab initio modeling
RosettaDDGFor estimating the impact of sequence changes on protein stability
RosettaScriptsAn xml-based scripting language for control of modeling trajectories. Supports all major Rosetta functionalities
RosettaSnugDockEnables docking an antibody Fv region to an antigen and allows backbone flexibility in the paratope.
RosettaMultigraftPerforms matching, backbone, and side chain grafting of functional motifs onto scaffold proteins.

Pay Attention!

The following applications are located only in the previous releases of Rosetta: RosettaDDG, RosettaAntibody and RosettaSnugDock

PyRosetta - Interactive Molecular Modeling

PyRosetta is an interactive Python-based interface to the powerful Rosetta molecular modeling suite. It enables users to design their own custom molecular modeling algorithms using Rosetta sampling methods and energy functions. PyRosetta is available through http://www.pyrosetta.org/.

Fold It - Predicting protein structure with a multiplayer online game

Foldit is a revolutionary new computer game enabling you to contribute to important scientific research. Foldit is available through http://fold.it/portal/

Development Background

Rosetta development began in the laboratory of Dr. David Baker, who is a Howard Hughes Medical Institute investigator as well as a professor in the Department of Biochemistry. Rosetta development is guided by the members of the Rosetta Commons, which is a collaborative research and software development environment of multiple universities and research institutes. Funding for the development of Rosetta has been provided by the Packard Foundation, the National Science Foundation, and the National Institutes of Health.