Rosetta Commons drives innovation in biomolecular modeling and design through cutting-edge computational methods and shared software. Our global community of scientists collaborates to advance open, reproducible science and accelerate discovery.
Latest News
Tech Tea Time – New Community Meeting series
Our first TechTeaTime, a new community meeting series event, happened on January 26, with 46…
Protein design workflows series kick off with Protflow and Ovo
On January 20, the protein design community kicked off a new Protein Design Workflows meeting…
Using protein design experiments to guide energy-function development
Why this matters When a protein is designed on a computer, tiny “impossible overlaps” between…
Rosetta Commons postdoc info sessions happening soon
The JEDI committee is hosting a two-part virtual info session spotlighting postdoctoral opportunities across the…
Optimizing Stability in Dynamic Small-Molecule Binding Proteins
Why this research matters Many proteins must change shape to function. For proteins that bind…
Quarterly PyRosetta builds now available
We are happy to announce the availability of quarterly PyRosetta builds. These builds provide persistent…
Stable de novo protein design via joint conformational landscape and sequence optimization
Why this research matters Protein design only works if a designed sequence reliably folds into…
Bridging Borders in Protein Design in Latin America – The AI4PD Workshop in Patagonia
Puerto Varas, Chile — in November, the stunning landscapes of Chilean Patagonia, including the Llanquihue…
Designing new enzymes around catalytic arrays with Riff-Diff
Markus Braun, Adrian Tripp, and colleagues from the Oberdorfer lab at Graz University of Technology…
RFdiffusion3 is Now Available in foundry
The RFdiffusion3 (RFD3) training and inference code is now available through foundry. This third-generation model…
Featured story
AtomWorks & RosettaFold3 (in ModelForge) now open-source on GitHub
Sep 15, 2025
We’re excited to share that two major repositories are live on the RosettaCommons GitHub: AtomWorks and ModelForge. AtomWorks is a broadly applicable data framework for…
Upcoming Events
Rosetta Megathon (Mega-Hackathon) is on March 2-6, 2026, in San Juan, Puerto Rico
Summer RosettaCon 2026 is on Aug 3-7, 2026, at the University of Washington in Seattle, WA.