Advancing biomolecular science through open collaboration

Rosetta Commons drives innovation in biomolecular modeling and design through cutting-edge computational methods and shared software. Our global community of scientists collaborates to advance open, reproducible science and accelerate discovery.

Latest News

Foundry Docker Image Now Available

February 25, 2026

Rosetta Commons now offers an official Foundry Docker image designed to make it dramatically easier…

Summer RosettaCon 2026 registration is now open

February 25, 2026

We are pleased to announce that Summer RosettaCon 2026 will take place at the University…

CyclicMPNN adapts sequence design to cyclic backbones

February 25, 2026

Why this work matters Cyclic peptides are attractive scaffolds because their closed backbone can promote…

Angela Colbert joins Rosetta Commons as Communications Lead

February 25, 2026

Angela Colbert, Ph.D., joined us on February 23 as our new Communications Lead. She comes…

Engineering a protein biosensor to detect common NSAIDs in wastewater

February 25, 2026

Why this research matters Pharmaceuticals often end up in wastewater after use, and monitoring them…

Registration open: Immunogen design workshop at Vanderbilt

February 25, 2026

The Meiler Lab at Vanderbilt University will host an in-person workshop, Computationally Guided Immunogen Design…

Documentation Playbook Now Available

February 25, 2026

The Documentation Playbook is a new guide designed to make writing and maintaining documentation for…

Ultra-large virtual screening using a motif-guided Rosetta pipeline validated in zebrafish

February 25, 2026

Broader significance: a screenable path from computation to in vivo Virtual screening can now evaluate…

Protein design workflows series kick off with Protflow and Ovo

January 28, 2026

On January 20, the protein design community kicked off a new Protein Design Workflows meeting…

Tech Tea Time – New Community Meeting series

January 28, 2026

Our first TechTeaTime, a new community meeting series event, happened on January 26, with 46…

Featured story

AtomWorks & RosettaFold3 (in ModelForge) now open-source on GitHub

Sep 15, 2025

We’re excited to share that two major repositories are live on the RosettaCommons GitHub: AtomWorks and ModelForge.  AtomWorks is a broadly applicable data framework for…

Upcoming Events

Rosetta Megathon (Mega-Hackathon) is on March 2-6, 2026, in  San Juan, Puerto Rico

Summer RosettaCon 2026 is on Aug 3-7, 2026, at the University of Washington in Seattle, WA.