Advancing biomolecular science through open collaboration

Summer RosettaCon 2026 registration is now open!

Rosetta Commons drives innovation in biomolecular modeling and design through cutting-edge computational methods and shared software. Our global community of scientists collaborates to advance open, reproducible science and accelerate discovery.

Latest News

AtomWorks & RosettaFold3 (in Foundry) now open-source on GitHub

September 15, 2025

We’re excited to share that two major repositories are live on the RosettaCommons GitHub: AtomWorks…

RFdiffusion3 is Now Available in foundry

December 22, 2025

The RFdiffusion3 (RFD3) training and inference code is now available through foundry. This third-generation model…

Next Generation Generative Model Unlocks de novo Designs at Scale

April 20, 2026

Key Takeaways: NVIDIA’s new Proteina-Complexa model combines generative AI with inference-time search algorithms to operate…

Deep Learning’s Impact on de novo Protein Design

April 24, 2026

Key Takeaways: With advancements in AI, the field of protein engineering has shifted from template-based…

Parametric disasters

May 18, 2020

I recently got a new computer and I have been (slowly) going through my old…

Standing up against hate and acts of violence

March 30, 2021

Dear all, Along with all members of our community, we are heartbroken by the recent…

Rosetta Commons Black Lives Matter Statement

June 3, 2020

Trigger warning: mentions acts of violence and racism We, as members of the Rosetta Commons,…

How to Improve Psychological Safety in Your Lab

May 26, 2021

Overview of Psychological Safety Psychological safety was first described over thirty years ago and has…

The eternal debate – one score function to rule them all?

April 19, 2021

Molecular modeling packages use various types of score functions, depending on the task and their…

Streamlining the RosettaScripts Interface: SimpleMetrics in protocols

September 8, 2021

SimpleMetrics are a flexible way to perform analysis on your structures. They are a much…

Featured story

AtomWorks & RosettaFold3 (in ModelForge) now open-source on GitHub

Sep 15, 2025

We’re excited to share that two major repositories are live on the RosettaCommons GitHub: AtomWorks and ModelForge.  AtomWorks is a broadly applicable data framework for…

Upcoming Events

Summer RosettaCon 2026 is on Augsut 3 - 7, 2026, at the University of Washington in Seattle, WA.

workshop covers

European RosettaCon is October 28 - 30, 2026, at NOVA University Lisbon in Portugal.