Rosetta Commons drives innovation in biomolecular modeling and design through cutting-edge computational methods and shared software. Our global community of scientists collaborates to advance open, reproducible science and accelerate discovery.
Latest News
De Novo Protein Design Overcomes Gene Editing Limits to Sustain CAR-T and TCR-T Cell Function
Key Takeaways De novo designed proteins bind and modulate entire target families simultaneously, bypassing the…
New OpenBind-0 model and dataset benchmark co-folding tools in drug discovery
Key Takeaways OpenBind-0 (OB0) is a fully open-source co-folding model built on OpenFold3, trained on…
Integrating Mass Spectrometry Restraints into Rosetta and AlphaFold Modeling Pipelines
Key Takeaways Integrating mass spectrometry data with computational modeling platforms like Rosetta and AlphaFold2 improves…
Brazil’s Largest Open Science Event Introduces Thousands to Protein Design with Foldit
For the second year in a row, Brazil’s largest open science event introduced thousands of…
Motivated Trainees and Tutors Shine at FEBS Advanced Practical Course
On April 19-24, 2026, 36 international participants gathered in Blankenberge, Belgium, for the FEBS Advanced…
Debating the balance between model openness and biosecurity guardrails
Key Takeaways The scientific community is currently debating how to balance open research with biosecurity…
Biohub releases open source models that utilize evolution to design disease target binders
Key Takeaways Biohub has released open source ESM protein language models that use evolutionary data…
OpenBind releases initial structure and affinity dataset for structure-based machine learning
Key Takeaways OpenBind is generating dense, high-quality protein-ligand datasets that link structural data with binding…
Summer 2026 Workshop Registrations Now Open
Two exciting week-long workshops this summer are now accepting applications. On July 20 – 24,…
Upcoming Events
Summer RosettaCon 2026 is on August 3 - 7, 2026, at the University of Washington in Seattle, WA.
European RosettaCon is October 28 - 30, 2026, at NOVA University Lisbon in Portugal.