Hii All
I am looking forward for idealizing and then refining a dimeric protein , but, using a fragment library for a monomeric protein. Use of a dimeric fragment library joins the two monomers into one single protein chain.
Thanking you
Post Situation:
Hi,
the answer depends on how you run Rosetta, but the easiest way seems to be to combine the two protein sequences into one and pick fragments for this hybrid. You should also tell somehow Rosetta about the chain break.