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documentation written by Jonathan Weinstein jonathan.weinstein@weizmann.ac.il, Nov 2017
Calculates the difference of the AA composition of every TM with that of natural TMs. natural TM amino-acid composition based on Liu, Y., et al. 2002, ‘Genomic analysis of membrane protein families: abundance and conserved motifs.’. as leucine is the most hydrophobic residue in the dsTbL insertion profiles (see MPResidueLipophilicityEnergy, a minimization will substitute every possible membrane facing residue to leucine. when wishing to design with more variability use sigmoids and GenericMonteCarlo, to optimize this filter and the total score.
<TMsAACompFilter name="(& string) threshold="(0.0 Real)/>