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This mover will mutate residues to the most-frequently occuring residues in a multiple sequence alignment, while making sure that the new residue scores well in rosetta. It takes a position specific scoring matrix (pssm) as input to determine the most frequently occuring residues at each position. The user defines a packer task of the residues which will be designed. At each of these positions only residues which appear as often or more often (same pssm score or higher) will be allowed in subsequent design. Design is then carried out with the desired score function, optionally adding a residues identity constraint proportional to the pssm score (more frequent residues get a better energy).
<ConsensusDesignMover name="&string" scorefxn="(&string)" invert_task="(&bool)" sasa_cutoff="(&float)" use_seqprof_constraints="(&bool)" task_operations="(&string)"/>