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Introduce a random mutation in a position allowed to redesign to an allowed residue identity. Control the residues and the target identities through task_operations . The protein will be repacked according to task_operations and scorefxn to accommodate the mutated amino acid. The mover can work with symmetry poses; simply use SetupForSymmetryMover and run. It will figure out that it needs to do symmetric packing for itself.

This can be used in conjunction with GenericMonteCarlo to generate trajectories of affinity maturation.

<RandomMutation name="(&string)" task_operations="(&string comma-separated taskoperations)" scorefxn="(score12 &string)"/>

See Also