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Post-doctoral Position in Protein Signaling and Design in the Laboratory of Protein and Cell Engineering

The Laboratory of Protein and Cell Engineering at the Institute of Bioengineering of the Ecole
Polytechnique Federale de Lausanne ( is looking for a
talented and motivated post-doctoral fellow with a strong background in protein biophysics,
biochemistry and molecular biology.

Our laboratory (

We belong to the Institute of Bioengineering at EPFL and are also part of the Ludwig Institute
for Cancer Research (LICR) in Lausanne. While EPFL provides a world class environment for
basic science and engineering, the LICR fosters translational applications of basic discoveries
to cancer medicine at the highest level. Our laboratory benefits from this dual exciting
environment and interdisciplinary approaches are essential to our research. We work at the
interface of biophysics, chemical, structural, computational and cell biology to uncover the
molecular principles that regulate protein and cellular signaling. Using this understanding, we
(1) design protein systems with novel biosensing and signaling functions for synthetic biology
and engineered cell therapeutic applications; (2) predict the effects of genetic variations on
protein structure/function for personalized cancer medicine applications.


This specific project involves: 1) the design of receptors (e.g. GPCRs) with novel ligand binding
and signaling properties and their characterization using in vitro and cell-based assays, or 2)
the design and characterization of novel inhibitors targeting membrane receptors of therapeutic
interest. The candidate will have the opportunity to learn and apply computational modeling
and design techniques of the software Rosetta and collaborate with computational scientists
in our lab. This position is open immediately.


Candidates must have a strong background in protein biochemistry, biophysics and molecular
biology and a good knowledge of structural biology. Candidates with strong expertise in some
of the following areas are particularly welcome to apply : mammalian, insect cell cultures,
membrane protein expression, purification and crystallography, cell signaling, protein
engineering, protein directed evolution. In addition, candidates should have a record of
relevant publications in peer-reviewed international journals, the ability to speak and write
effectively, strong team skills, be self-motivated, and creative.

EPFL provides state-of-the-art facilities and is one of the leading technical universities
worldwide. A competitive salary is offered. Interested applicants should send a curriculum
vitae, a statement of research interests, and names of three references in one pdf-file to (subject: post-doc position).