I am trying to design the surface of a protein to increase solubility and decrease aggregation. I was able to find the Kuhlman lab paper "Computational protein design with explicit consideration of surface hydrophobic patches." In this paper they had a scoring function hpatch. I looked and as part of the rosetta_scripts scoring functions weights files a design_hpatch.wts was listed. I then implemented a scoring function based on this, as shown below. When I use the hpatch scorefunction I get the segmentation fault. When I replace it with a regular scorefunction the run completes as normal. I am attaching the run output leading up to the segmentation fault. Originally this paper suggests to use fixbb design. When looking through the rosetta script documentation they said to use PackRotamersMover instead.
Any help would be appreciated.
<ScoreFunction name="hpatch" weights="design_hpatch" symmetric="0"/>
<ScoreFunction name="regular" weights="talaris2014" symmetric="0" />
<OperateOnResidueSubset name="protein_surface" >
<Layer select_surface="true" />
<FavorNativeResidue name="native" bonus="1.5" />
<PackRotamersMover name="design" scorefxn="hpatch" task_operations="protein_surface" />