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about deNovoProteinMimeticsGen2

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about deNovoProteinMimeticsGen2
#1

Good morning everyone~ 

Recently, I had read the paper entitled "De novo design of potent and selective mimics of IL-2 and IL-15”

And I am very interesting in it, and I want to learning how to performing it in using pyrosetta. 

However, in the Code availability section, I can not find any information about the submodule 

‘pyrosetta_scripts/apps/deNovoProteinDesign/deNovoProteinMimeticsGen2/' . Even I download the newest weekly version(rosetta_src_2018.48.60516_bundle) and pyrosetta(PyRosetta4.Release.python27.mac.release-206).

Are there some one tell me how can i found these script?

Thank you!

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Mon, 2019-01-14 17:09
zhangying1990

Hi,

Sorry (for the delay), you are looking in the right place. Aka this:

pyrosetta_scripts/apps/deNovoProteinDesign/deNovoProteinMimeticsGen2

But, I forgot to push my commit to origin earlier, so it is now delayed.

It has been pushed now, it will def-come out with the next release. Sorry.

(BTW: It has a HOWTO that explains how to run a completely worked-out example)

Best,
Daniel

 

commit fd8934afab2797b48754dfb6df2eed537b5b9e92

Merge: b52f26b 24873cd

Author: dadriano <dadriano@mia.local>

Date:   Mon Jan 14 21:54:35 2019 -0800

    Merge remote-tracking branch 'origin/master' adds: deNovoProteinMimeticsGen2

    Added DeNovoProteinDesign deNovoProteinMimeticsGen2 algorithm

    Refers to Nature publication doi: 10.1038/s41586-018-0830-7

    De novo design of potent and selective mimics of IL-2 and IL-15

    D-A Silva, S Yu, U Y. Ulge, J B. Spangler, et.al., 01/10/2019, Nature

Mon, 2019-01-14 22:21
dsilva

Thank you for your reply! Looking forward to studying on it!!!

 

Tue, 2019-01-15 00:25
zhangying1990