I have some questions about setting for scoring and weights. That would be really helpful if someone could answer the questions.
I looked into the folder> Rosetta/main/database/scoring, there are loads of score files.I'm wondering How to choose the right one.
Should I just use one for all applications? For example, If I use Rosetta3.12, should I use ref2015.wts for relax, loopmodel,etc?
Could someone please kindly explain to me what's the difference between these score files?
I'd like to use rosetta to model a loop region based on EM density.
I got a flag file from my colleague, in which -edensity:whole_structure_allatom_wt is 0.05. -score:weights score13_env_hb. (He used Rosetta 3.7)
But I found one online tutorial updated on 2018 , the setting is -edensity_dens_fast_wt 35. Does the difference come from different rosetta version?
Thanks a lot,