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Repacker vs minimization

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Repacker vs minimization

Hey all! I am quite new to Rosetta so I am hoping someone here may be able to help me. I am trying to minimize the energy of a protein in which a point mutation has been made. I have looked through quite a few papers and many of them mention the repacker tool in addition to the minimization tool. From my understanding, it looks like I would want to use the repacker first and then do overall minimization of the protein. Is this correct? I am mainly confused on when I should use the repacker and if I am supposed to use it in conjunction with the minimization tool. Thanks!

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Fri, 2021-07-02 07:25