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Local docking- should I use KIC?

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Local docking- should I use KIC?
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Hi, I'm kind of new to Rosetta. 

I am trying to dock GPCR and G protein complex using local docking, but it turns out that there is some clashes between Interloop 2 and G alpha subunit. How can I solve this problem? Should I use KIC for loop modeling and then use local docking application? 

Could you please help me solve this problem?

 

Thank you

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Fri, 2022-05-27 02:45
seayoung lee