This is a general question,
Is there any example of proteins modeled by ROSETTA which is currently being used in industry, whether it is enzymes or therapeutics or any other biomolecules?
Thanks.
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The hub for Rosetta modeling software
Industry plays its cards close to the vest so we don't know what they've actually used Rosetta for. It's also true that they'd use Rosetta as a part of a long pipeline, with many other tools used along the way.
The Kuhlman lab developed a bispecific antibody technology in collaboration with Eli Lilly. (http://www.ncbi.nlm.nih.gov/pubmed/24463572, http://www.ncbi.nlm.nih.gov/pubmed/25774965). I assume Lilly is finding it useful, and there is a spinoff company http://www.dualogics.com/ which is commercializing it as well.
Arzeda (http://arzeda.com/) offers enzyme design, they certainly started using Rosetta, and I assume they are using it now; probably many of their products have had Rosetta's hand in it.
Why do you need to know?
I was giving a talk with explanation of computational protein modeling in some slides and was asked the question. I included application examples from publications but didnt know of an actual example where molecules modeled with ROSETTA have been used to produce or is an ingredient of products used everyday. I tried to search the web but as you mentioned its probably confidential info so I couldnt find anything interesting. if you know of anyother examples, whether ROSETTA or other computational modeling softwares, any comments will be appreciated. thanks for your reply.
Here's another on the antibody thread that Andrew passed along:
http://www.sciencedirect.com/science/article/pii/S0969212616000721
Here's two more from Florian:
"
There is also this paper
http://www.ncbi.nlm.nih.gov/pubmed/21168766
though I don't know if the obtained enzyme is really used in an industrial process.
the enzyme here
http://www.ncbi.nlm.nih.gov/pubmed/25313043
has been patented, but I don't know if anyone has licensed the patent and/or is marketing the enzyme
"
Also, cryptically, "and I guess kumamax is also a very good example" - I know nothing more there than google.
thanks steven. :)