Dear Rosetta users,
I have a symmetrical homo-dimeric structure for which I would like to select a single point mutation that will increase the affinity between the monomers. I thought about design&relax protocol, in which one position is designed while the remaining ones are only allowed to repack. Such a protocol would be used to scan all the interface positions.
My questions is how to set up this in Rosetta Scripts? Perhaps there are easier/better ways to do this?
Thanks for help! Staszek