Just wanted to confirm there is no semi-official script or protocol for DMS using Rosetta and ddg cartesian?
Seems like an easy enough thing to script using existing methods and protocols....but ideally, I would like a strategy that avoided generating 19 WT models per-site, per-iteration (since just one set would suffice for all DDGs).
That would same me a lot of comput time. For a 500aa protein with 10 iterations per DDG estimate, that would save me from building (18x500x10=90,000 superfulous models.
Does anyone have a suggestions (or a script) that can do this?
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