I started learning PyRosetta in December 2014 using the newest workshops currently available and a number of other online resources. I would like to learn how to design protein scaffolds and enzymes de novo, and to that end I am currently trying to see if I can achieve a specific small protein topology using pre-defined secondary structure characteristics, similar to the strategy used in the Kuhlman et al. 2003 paper on the design of Top7. I am trying to make use of the RosettaModel blueprint to set the lengths of each secondary structure component and other hydrogen bonding constraints, but I cannot find documentation on how to use the blueprint in PyRosetta through Ipython. I tried out the pyrosetta toolkit as well, but it does not seem as though blueprints can currently be created via the GUI. Any recommendations are appreciated!
Thanks a lot for your help,