Hamiltonian Exchange
I ran the below command for docking ;
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The problem hasn't been solved
I ran the below command for docking ;
I ran the below command for docking ;
Hello everyone!
I am getting this following error when I am trying to run a rosettaDNA application program in which i want to change the specificity of a protein so that it binds to a target DNA. In most published articles, I have seen "hack_elec 0.42 " or similar values. However, it's not working in my case. Can you help me with this?
Hello, I am a postdoc at the Max Planck Istitute for Chemical Ecology and would to use ROSIE for acedemic purposes. My email adress scarr@ice.mpg.de is not recognized.
I posted this same request a few weeks ago and got no responce. Any help would be greatly apreaciated. Cheers
Hello!
I am trying to run the default XML script to change the specificity of a protein so that it binds to a DNA sequence of interest. For this I am referring to the book Redesigning the specificity of protein-DNA interactions with Rosetta
Thyme S, Baker D. Redesigning the specificity of protein-DNA interactions with Rosetta. Methods Mol Biol. 2014;1123:265-82. doi: 10.1007/978-1-62703-968-0_17. PMID: 24510272.
However I am getting the following error message.
Hi,
I observed that the current default number of Monter Carlo cycles (-cycles option) for rna_denovo is 100000. If it is reduced to 20000, does it significantly affect the accuracy of the models built?
TIA,
Mandar
Bit of a complicated issue here so apologies in advance if it's not entirely clear - happy to provide clarification.
Hey guys, I counterpart with problems as topic saying:
First, I want to use others computational results as reference to optimized docking option, so I have to relax them into same scorefunction, meanwhile relax the inputs which generate from different methods for better results and avoid disulfide bonds error due to different scorefunction, right?
Hello all,
I have been trying to dock a library of ligands to a protein while following the Meiler lab tutorials. While I have been able to prepare most of the prerequisite files, I am unsure how I am supposed to obtain 'crystal_complex.pdb'. Trying to download the protein bound with a ligand .pdb file from the protein data bank and using that as my crystal_complex.pdb does not seem to work. While it seems that options.txt and dock.xml have been set up correctly, protein complex.pdb is the only thing preventing me from running the docking itself.
Hello! I'm trying to run add some missing loop to my protein by appear segmentation fault as error.
Anyone have an idea to solve this issue?
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